The Movie Poster for How to Lose Friends & Alienate People by Matt Richenthal at August 20, 2008 11:14 am. Comments Based on a famous memoir by the same name, How to Lose Friends & Alienate People comes out on October 3. The film boasts a cast that includes Gillian Anderson, Jeff Bridges and Megan Fox. Here's the poster for the film: Edit Delete Share Tweet Email