Reilly plays Wreck-It Ralph, an 8-bit arcade game villain, who grows tired of the bad-guy routine and escapes to another game. The trailer features a great scene of a villain support group, with some of video game history's most iconic villains.
Reilly has long been a prolific supporting actor, but has recently been proving his capabilities as a leading man, beginning with his role in 2008's Step Brothers (check out some Step Brothers quotes). With such a unique voice, it's a wonder he's never lent his voice to an animated film before.
Wreck-It Ralph is directed by Simpsons director Mark Rich Moore. It opens in 3D on November 2.