Zach Galifianakis' Between Two Ferns has truly become a pop culture comedy legend. Heck, the comic even scored a visit from President Obama.
Let's just say that Galifianakis starts by asking Pitt when he lost his virginity!
Check out the video above from Funny or Die and prepare to squirm with Pitt as things get silly! And things get really weird when Galifianakis invites Louis CK out to do stand-up in the middle of the interview.
And check out our favorite quotes from Pitt's latest, Fury, in the slideshow below.