Alice (Natalie Portman) moonlights in a strip joint where she encounters Larry (Clive Owen). Their respective relationships with Dan (Jude Law) and Anna (Julia Roberts) are the center of this dramatic exploration of love and deceit.
Larry is a dermatologist in Closer. He meets Anna via a cyber sex chat/set up and the two hit it off. Later on in the film, Larry gets together with Alice, a lying stripper. It's all part of the film's intertwined sex stories.