U.S. Marshal Samuel Gerard (Tommy Lee Jones) replies - with his own gun pointed at him - that he doesn't care that Dr. Richard Kimble claims he's innocent of killing his wife. A defining scene in a very good movie.
Dr. Richard Kimble! There's no way out of here, Richard! The entire building is locked down! Give it up Richard, you don't have any time, Chicago police department thinks you're a cop killer, they WILL shoot you on sight!