One of the Spierig brothers on set with Ethan Hawke.

Once vampires mutate into subsiders, there's only one way to cure them... kill them.

Emma Randall plays Ellie Landon, a human survivor and member of Elvis' rebel human group, which is trying to spread the vampire cure.

Edward (Ethan Hawke) and Elvis (Willem Dafoe) sneak up behind their foe with crossbows.

Elvis, Audrey and Edward ready their crossbows.

Elvis (Willem Dafoe) helps Edward (Ethan Hawke) hide from Bromley's goons.

Charles Bromley (Sam Neill) heads up an evil corporation that is hell-bent on keeping the vampire populace from finding a cure that would revert them back to regular humans.

When vampires don't consume enough blood, they mutate into horrific predatory creatures known as Subsiders. Edward Dalton (Ethan Hawke) is tasked by Charles Bromley (Sam Neill) to find a blood substitute in order to prevent this from happening.

Elvis (Willem Dafoe) aims his crossbow at oncoming vampires.

Edward Dalton (Ethan Hawke) helps Audrey Bennett (Claudia Karvan) hide from pursuing vampires.

Edward Dalton (Ethan Hawke) waits at a subway platform in a future where vampires rule the world and humans are hunted like animals.

Edward Dalton (Ethan Hawke) decides to help Elvis (Willem Dafoe) and the rest of the surviving humans.