Jason Bourne (Matt Damon) is a marked man. In "The Bourne Supremacy," he finds himself targeted after he is framed for a hit job gone awry. He therefore resorts to his old tactics in order to keep on living.
They should have left him alone. In "The Bourne Supremacy," the spy thriller from 2004, Jason Bourne is framed for a botched CIA operation, and is thus forced to take up his former life as a trained assassin - in order to survive.