Dr. Richard Kimble (Harrison Ford) was convicted of murder but escaped before he could be incarcerated. Now he's on the lam and out to clear his name, while a massive manhunt for him is led by Sam Gerard (Tommy Lee Jones) and his fellow U.S. Marshals.
U.S. Marshal Samuel Gerard (Tommy Lee Jones) replies - with his own gun pointed at him - that he doesn't care that Dr. Richard Kimble claims he's innocent of killing his wife. A defining scene in a very good movie.