Chris Klein was born and raised in Hinsdale, Illinois until his family moved to Omaha, Nebraska. At Millard West High School, Klein acted and played quarterback and linebacker for the football team. During his senior year, Klein was recruited by director Alexandere Payne for his role in the movie, Election.
Shortly after, Klein would star in his best known role to date as Chris 'Oz' Ostreicher in American Pie. Klein has also appeared in the American Pie sequel, Rollerball and Just Friends.
In his personal life, Klein is known for dating Katie Holmes from 2000 to 2005. The couple was engaged in 2004.