GH-7 Medical Droid: Medically, she is completely healthy. For reasons we can't explain, we are losing her.
Obi-Wan: She's dying?
GH-7 Medical Droid: We don't know why. She has lost the will to live. We need to operate quickly if we are to save the babies.
Senator Bail Organa: Babies?
GH-7 Medical Droid: She's carrying twins.

Anakin Skywalker: [uses Force grip on Padme]
Obi-Wan Kenobi: Let her go, Anakin!
Padmé: [suffocating] Anakin...
Obi-Wan Kenobi: Let. Her. Go.
Anakin Skywalker: [releases Padme, she falls unconscious] You turned her against me!

[to Obi-Wan] You fool. I have been trained in your Jedi arts... by Count Dooku.

General Grievous

Not even the younglings survived.

Obi-Wan

Anakin Skywalker: What was that all about?
Obi-Wan: Well, R2 has been...
Anakin Skywalker: No loose wire jokes.
Obi-Wan: Did I say anything?
Anakin Skywalker: He's trying.
Obi-Wan: I didn't say anything.

Darth Sidious: Commander Cody, the time has come. Execute Order 66.
Commander Cody: Yes, my Lord.

I am sending you my apprentice, Darth Vader. He will... take care of you.

Darth Sidious

Padmé: I don't believe what I'm hearing... Obi-Wan was right... you've changed!
Anakin Skywalker: I don't want to hear any more about Obi-Wan. The Jedi turned against me; don't you turn against me!

The Emperor: [to the Senate] In order to ensure our security and continuing stability, the Republic will be reorganized into the first Galactic Empire, for a safe and secure society which I assure you will last for ten thousand years.
Padmé: [to Bail Organa] So this is how liberty dies... with thunderous applause.

[addressing the Separatist leaders] It won't be long before the armies of the Republic track us here. I am sending you to the Mustafar system in the Outer Rim. It is a volcanic planet which generates a great deal of scanning interference. You will be safe there.

General Grievous

Obi-Wan: [switches off hologram] I can't watch any more.
Yoda: Destroy the Sith we must.

Hold me, like you did by the lake on Naboo; so long ago when there was nothing but our love. No politics, no plotting, no war.

Padmé

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Star Wars: Episode III - Revenge of the Sith Quotes

Darth Vader: Where is Padme? Is she safe? Is she all right?
Darth Sidious: It seems in your anger... you killed her.
Darth Vader: I... I couldn't have! She was alive; I felt it... I... Nooooooo!

Supreme Chancellor: Did you ever hear the tragedy of Darth Plagueis "the wise"?
Anakin Skywalker: No.
Supreme Chancellor: I thought not. It's not a story the Jedi would tell you. It's a Sith legend. Darth Plagueis was a Dark Lord of the Sith, so powerful and so wise he could use the Force to influence the midichlorians to create life... He had such a knowledge of the dark side that he could even keep the ones he cared about from dying.
Anakin Skywalker: He could actually save people from death?
Supreme Chancellor: The dark side of the Force is a pathway to many abilities some consider to be unnatural.
Anakin Skywalker: What happened to him?
Supreme Chancellor: He became so powerful... the only thing he was afraid of was losing his power, which eventually, of course, he did. Unfortunately, he taught his apprentice everything he knew, then his apprentice killed him in his sleep. It's ironic he could save others from death, but not himself.