Kirk: You're suffering from a Vulcan mind-meld, doctor.
McCoy: That green-blooded son of a bitch! It's his revenge for all the arguments he lost.

The more they overthink the plumbing, the easier it is to stop up the drain.

Scotty

Kirk: How are we doing?
McCoy: How are "we" doing? Funny you should put it quite that way, Jim. "We" are doing fine.

Saavik: Humor. It is a difficult concept. It is not logical.
Kirk: We learn by doing.

[quoting from Melville's Moby Dick] To the last, I will grapple with thee... from Hell's heart, I stab at thee! For hate's sake, I spit my last breath at thee!

Khan

There she is! There she is! Ah... not so wounded as we were led to believe. So much the better!

Khan

Every time we have dealings with Starfleet, I get nervous.

David Marcus

[describing Khan] I'll give him this

Kirk

[to Spock] Are you out of your Vulcan mind?

McCoy

Damn it Jim, what the hell is the matter with you? Other people have birthdays, why are we treating yours like a funeral?

McCoy

Scotty, I need warp speed in three minutes or we're all dead!

Kirk

He is intelligent, but not experienced. His pattern indicates two-dimensional thinking.

Spock

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