John Jameson: Thought he was your pal.
Mary Jane Watson: Peter Parker?
John Jameson: Yeah.
Mary Jane Watson: Uh, he's just a great big jerk.
John Jameson: Well, the world's full of great big jerks.
Danny: Now, they tell me I paid my debt to society.
Tess: Funny, I never got a check.
Bartender: [over the background noise] How's the game going?
Rusty: Longest hour of my life.
Bartender: [not hearing him] What?
Rusty: I'm running away with your wife.
[discussing his son's wedding with his wife over the phone] Flowers? How much? If you spend any more on this thing, you can pick the daisies off my grave! Get plastic!J. Jonah Jameson
I should have known Osborn wouldn't have the guts to finish you.Dr. Otto Octavius
[Peter apologizes for a previous conversation] Pish-posh. We needn't talk about it. Water over the dam, or under the bridge, or wherever you like it.May Parker
Guy named Otto Octavius winds up with eight limbs. What are the odds?J. Jonah Jameson
[to Peter Parker] Get your pretty little portfolio off my desk before I go into a diabetic coma!J. Jonah Jameson
J. Jonah Jameson: My god, he was a hero. Spider-man truly was an asset to this city. He was...
J. Jonah Jameson: [the Spider-man costume is gone] ... a thief! A burglar. Get me Spider-man now! I want his head!
Peter Parker: [speaks to MJ through a dead phone line] I wanna tell you the truth... here it is: I'm Spider-Man. Weird, huh? Now you know why I can't be with you. If my enemies found out about you... if you got hurt, I could never forgive myself. I wish I could tell you how I feel about you...
Rosalie Octavius: You need to sleep soundly tonight.
Dr. Otto Octavius: Did Edison sleep before he turned on the light bulb? Did Marconi sleep before he turned on the radio? Did Beethoven sleep before he wrote the fifth?
Peter Parker: Did Bernoulli sleep before he found the curves of quickest descent?
Dr. Otto Octavius: Ahhh, Rosie, I love this boy.
Doc Ock: [grabs Spider-Man in the bank] You're getting on my nerves.
Spider-Man: I have a knack for that.
Doc Ock: Not anymore.