This Golden Globe winner truly made a name for himself via the Spider-Man franchise. He also played Tristan in Tristan and Isolde, and showed a comedic touch, appearing in Judd Apatow's Pineapple Express. He was also the lead in The Rise of The Planet of The Apes, and will be playing Oz in Oz: The Great and Powerful.
James Franco plays himself in This Is the End, and some of his artwork is featured throughout. Franco took to the streets of Brooklyn and Los Angeles to paint a mural, inspired by the film, and we've got the video.